सर्वधर्मान्परित्यज्य मामेकं शरणं व्रज। अहं त्वा सर्वपापेभ्यो मोक्षयिष्यामि मा शुचः।।Gita.18.66।।

Whatsapp +91 7678626422     Email: rkvtg@yahoo.com
Cure, Treat and Manage Obesity, Diabetes and All Other Diseases.

Do not starve or punish your taste-buds when you can plan your food!

If Health is a Question of Life and Death for you, Do not let Mediocres and Pseudos Misguide You. Right choice matters the most!


13.12.2018 - By Dr Jyotsna Verma

To help patients with muscle disorders, scientists at The University of Texas Health Science Center at Houston (UTHealth) have engineered a new stem cell line to study the conversion of stem cells into muscle. Findings appeared in Cell Reports.



"We have also developed a more efficient strategy to make muscles from human stem cells. Scientists can use these cells for disease modeling, gene correction, and potential cell therapy," said Radbod Darabi, MD, Ph.D., the study's senior author and an assistant professor in the Center for Stem Cells & Regenerative Medicine at McGovern Medical School at UTHealth.

Muscle disorders such as muscular dystrophy cause muscles to weaken and deteriorate, and they affect more than 50,000 people in the United States. Symptoms include difficulty walking and standing. In severe cases, the disorders might involve cardiac and respiratory muscles and lead to death. There is no cure.

Darabi's team engineered a novel human stem cell line for skeletal muscle. To ensure the purity of the muscle stem cells, they tagged muscle genes (PAX7, MYF5) with two fluorescent proteins. "In order to improve the formation of the muscle from stem cells, we screened several bioactive compounds. We were also able to observe muscle stem cell activity in great detail using color tags," he said.

In the lab housed in the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at UTHealth, the team used a gene-editing method called CRISPR/Cas9 to add the fluorescent tags to the genes.

The stem cells were generated from a patient's skin cells and used to generate muscle. "Our current research provides a step-by-step roadmap to make muscle stem cells from these cells," Darabi said.

The team's "approach also allowed induction and purification of skeletal myogenic progenitors in a much shorter time course (2 weeks) with considerable in vitro and in vivo myogenic potential (myofiber engraftment and satellite cell seeding)," the authors wrote.

The modified stem cells produced promising results in a culture of human tissue, as well as in a mouse model of Duchenne muscular dystrophy. "In a side-by-side comparison with previous strategies, our strategy allowed faster and more efficient generation of muscle stem cells with superior engraftment in mice," Darabi said.

Darabi believes these muscle stem cells will initially be used by researchers to study the pathophysiology of muscular dystrophies, create disease models that scientists can use to test promising drugs, or evaluate gene correction efficiency.

Human bodies are constantly replacing skeletal muscle cells but muscle disorders make it difficult to replenish muscle due to the failure and exhaustion of muscle stem cells. It is Darabi's hope that the cells can one day be used as a form of stem cell therapy.




Recent Comments

Arnold Lepus - arnold_lepus@hotmail.com

I am highly thankful for your nutritional guidance. I got immensely benefitted. Be there to help people like us.

Tina Susane - t.susane@gmail.com

Excellent, Unimaginable, Wow, Great! Your Diet-plan is awesome. It was easy to impliment. Yummy food items encouraged me to follow it consistently.

Lucy Avon - avonlucy1215@gmail.com

Weight loss was a challenging and lonely journey for me. I am a doctor and know all about problems of obesity but I had never paid enough attention to myself and ended up being grossly overweight. I tried many things and everything - exercise, dieting, crash diets etc etc. I got trapped in Yo-Yo weight-loss. I would lose some weight and ended up gaining back again.It just was not happening and I often overate in stress. Then I tried Dr Jyotsna Verma's online dietary advise plan. I got a persolanised diet and exercise regime for me.It was custom made for me taking into account my lifestyle, job requirements and food habits. It worked miraculously and I shed 40 Pounds in one month. Thanks.

Ruma - ruma.perry@msn.com

Dr Jyotsna Verma - An expertise which is peerless. There are very

Read all Comments


Whatsapp and Mobile +91 7678626422

Email - rkvtg@yahoo.com

सर्वधर्मान्परित्यज्य मामेकं शरणं व्रज। अहं त्वा सर्वपापेभ्यो मोक्षयिष्यामि मा शुचः।।Gita.18.66।।



Pages viewed in Last Few Hours

Alzheimer Disease Cure and Treatment in Mandya, Karnataka        Diabetes Cure and Treatment in Halisahar, West Bengal        Heart Disease Cure and Treatment in Gurgaon, Haryana        Alzheimer Disease Cure and Treatment in Tiruvottiyur, Tamil Nadu        Brain Stroke Cure and Treatment in Thrissur, Kerla        Diabetes Cure and Treatment in Rohtak, Haryana        Diabetes Cure and Treatment in Banda, Uttar Pradesh        Diabetes Cure and Treatment in Surat, Gujrat        Brain Stroke Cure and Treatment in Sitapur, Uttar Pradesh        Brain Stroke Cure and Treatment in Vellore, Tamil Nadu        Respiratory Disease Cure and Treatment in Firozabad, Uttar Pradesh        Autoimmune Disease Cure and Treatment in Ozhukarai, Puducherry        Alzheimer Disease Cure and Treatment in Port Blair, Andaman and Nicobar Islands        Kidney Disease Cure and Treatment in Basti, Uttar Pradesh        Heart Disease Cure and Treatment in Jhansi, Uttar Pradesh        Heart Disease Cure and Treatment in Saharanpur, Uttar Pradesh        Liver Disease Cure and Treatment in Tonk, Rajasthan        Brain Stroke Cure and Treatment in Fatehpur, Uttar Pradesh        
Proudly Designed with MiMuR - Powered by Assembly, C and some PHP | Template: Dr Jyotsna Verma(MD)
Web Renaissance by www.oyegoogle.com